Measuring Glycolysis and Glucose Oxidation Coupling in Hypertrophic Cardiomyopathy Patients using Hyperpolarized [1-13C]-Pyruvate MRI

Motivation: Alterations in cardiac metabolism are implicated in numerous heart diseases, including cardiomyopathies, heart failure, and ischemic disease. Patients with hypertrophic cardiomyopathy (HCM) have known dysregulation of cardiac metabolism and energetics, and studies group aim to provide non-invasive measurements of dysregulation to allow for earlier diagnoses as well as monitoring of treatments. Goal(s): In this project, we aim to translate HP 13C-MRI into human studies of cardiac metabolism. Approach: This project will include studies of healthy subjects for normative values as well patients with HCM. Results: Preliminary results show clear abnormalities in metabolic imaging but no one metabolic phenotype across all five HCM patientsImpact: In this project, we aim to translate HP 13C-MRI into human studies of cardiac metabolism. Alterations in cardiac metabolism are implicated in numerous heart diseases, including cardiomyopathies, heart failure, and ischemic disease.