Direct Revascularization Improves Vascular Hemodynamics in Pediatric Moyamoya Patients

Motivation: Moyamoya is a progressive cerebrovascular disorder affecting hemodynamics and the disease often begins during childhood. However, the non-invasive assessments of hemodynamics in pediatric Moyamoya patients remain an open question. Goal(s): Investigate the CBF change before and after revascularization in pediatric Moyamoya patients. Approach: CBF in 42 patients was measured using arterial spin labeling on a 3T MRI 1 week before and within 2 weeks after revascularization. CBF in regions affected by vasculopathy was compared before and after revascularization. Results: CBF in regions affected by vasculopathy increased significantly after revascularization. Impact: ASL can be utilized to evaluate CBF in pediatric Moyamoya patients before and after direct revascularization.