Non-invasive high-resolution in vivo pH mapping in brain tumors by 31P‑informed deepCEST MRI
Motivation: The pH value is an important biomarker for many diseases. MRI-based 3D pH mapping for clinical routine would be an enormous benefit for diagnostics. Goal(s): Prediction of intracellular 31P-pHi maps from 1H APTw-CEST MRI data using a voxel-wise neural network, aiming to improve brain tumor imaging. Approach: Fifteen glioblastoma patients underwent 3T MRI with both APTw-CEST and 31P-MRS. A neural network trained on 11 patients data to correlate APTw-CEST features with 31P-derived pHi values, tested on 4 additional patients. Results: The neural network's pHi predictions closely matched 31P-pHi maps, showing potential for high-resolution, non-invasive pHi mapping in brain tumors. Impact: High resolution pH imaging for better diagnosis of diseases (inflammation, stroke, tumor) and therapy monitoring in clinical routine.
Authors
- Jan‐Rüdiger Schüre (ORCID: https://orcid.org/0000-0002-1472-9471)
- Junaid R. Rajput (ORCID: https://orcid.org/0000-0002-3869-6918)
- Moritz Fabian (ORCID: https://orcid.org/0000-0001-5437-8576)
- Moritz Zaiß (ORCID: https://orcid.org/0000-0001-9780-3616)
- Ralf Deichmann (ORCID: https://orcid.org/0000-0002-4110-1225)
- Eike Steidl (ORCID: https://orcid.org/0000-0001-7464-0236)
- Manoj Shrestha (ORCID: https://orcid.org/0000-0002-0129-2397)
- Armin Michael Nagel (ORCID: https://orcid.org/0000-0003-0948-1421)
- Elke Hattingen (ORCID: https://orcid.org/0000-0002-8392-9004)
- Andreas Maier (ORCID: https://orcid.org/0000-0002-9550-5284)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1085
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00