Application of Pancreatic ECV Fraction measured by T1-mapping MRI in predicting Impaired Glucose Tolerance in Chronic Liver Disease

Motivation: The mechanism of impaired glucose tolerance (IGT) in chronic liver disease (CLD) may be related to reduced insulin secretion caused by pancreatic fibrosis. Goal(s): This study aims to evaluating the value of T1-mapping MRI in quantifying pancreatic ECV fraction for predicting IGT in CLD. Approach: A total of 184 CLD patients were recruited in this study. Univariate and multivariate logistic regression analysis was conducted to identify independent predictors of IGT in CLD. Results: After adjusting for age, gender, body mass index(BMI), hypertension,estimated glomerular filtration rate(eGFR), cholesterol and triglycerides, pancreatic ECV fraction was identified as an independent predictor for IGT in CLD. Impact: The results suggest that pancreatic ECV fraction, quantified by T1-mapping MRI, may help elucidate the pathophysiological mechanisms of IGT in CLD.