CSF Outflow and Egress in Optic Nerve: Non-contrast MRI Revelations

Motivation: The rose of cerebrospinal fluid (CSF) in neural health is recognized, yet its outflow and egress within the optic nerve, especially amidst new findings about the glymphatic system, remains less explored. Goal(s): Investigate CSF interactions within the optic nerve using advanced MRI techniques, highlighting implications for conditions like glaucoma. Approach: Utilized advanced Time-Slip sequences on a 3-T MR imager, targeting specific brain regions to study CSF outflow and egress. Results: Clear CSF egress pathways through the optic nerve were found, with distinct outflow influenced by participants’ optical attributes. Impact: Enhances understanding of CSF outflow and egress, providing pivotal insights for addressing neuro-ophthalmological disorders like glaucoma.