Biomechanical properties and multiparametric MRI to identify microstructural dynamics in a non-alcoholic steatohepatitis mouse model
Motivation: The relationship between the microstructural changes and the imaging-based biophysical properties of the liver as NASH progresses are not fully established. Goal(s): We aim to identify quantitative imaging markers that can provide valuable insights into the microstructural progression of NASH. Approach: We established non-alcoholic steatohepatitis in mice with a defined amino-acid high-fat diet. We performed MRI, MR elastography and histological scoring with automated fat segmentation at different times during the course of NASH. Results: Our results shed light on liver viscosity and water diffusivity as potential quantitative markers of steatohepatitis progression in mice. Impact: This study highlights the role of multiparametric-MRI, MR elastography and histopathology to reveal the dynamics of microstructural changes of non-alcoholic steatohepatitis in a mouse model using a clinical scanner. We identify liver viscosity and water diffusivity as reliable quantitative markers.
Authors
- Christian Bayerl (ORCID: https://orcid.org/0000-0001-7107-3934)
- Jing Guo (ORCID: https://orcid.org/0000-0002-1170-8157)
- Patrick Asbach (ORCID: https://orcid.org/0000-0002-6885-3283)
- Heiko Tzschätzsch (ORCID: https://orcid.org/0000-0001-9458-2221)
- Anja A. Kühl (ORCID: https://orcid.org/0000-0003-2293-5387)
- Kristin Brüggemann
- Biru Huang
- Jakob Jordan (ORCID: https://orcid.org/0000-0002-6081-7595)
- Tom Meyer (ORCID: https://orcid.org/0000-0002-2171-6791)
- Yasmine Safraou (ORCID: https://orcid.org/0009-0009-7347-1552)
- Ingolf Sack (ORCID: https://orcid.org/0000-0003-2460-1444)
- Jürgen Braun (ORCID: https://orcid.org/0000-0001-5183-7546)
- Karolina Krehl (ORCID: https://orcid.org/0000-0003-3632-5854)
- Mehrgan Shahryari (ORCID: https://orcid.org/0000-0002-3981-1711)
- Noah Jaitner (ORCID: https://orcid.org/0009-0002-5647-593X)
- Pedro de Moraes
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3946
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00