Comparative Analysis of Contrast Agents for HCC Diagnosis Using LI-RADS 2018v

Motivation: Enhance precision in hepatocellular carcinoma (HCC) diagnosis by determining the superior contrast agent. Goal(s): Compare Gd-EOB-DTPA and Gd-BOPTA efficiency in displaying LI-RADS-recommended HCC features. Approach: Retrospective analysis of 98 HCC lesions using Gd-EOB-DTPA-MR and Gd-BOPTA-MR, assessing enhancement patterns and lesion-to-liver contrast. Results: Significantly varied capsule enhancement and lesion-to-liver contrast were observed in specific phases. Both agents demonstrated effective display capabilities (AUC>0.750) and excellent overall performance (AUC>0.950) across all phases. Impact: These findings offer crucial insights for clinicians and researchers, facilitating informed selection of contrast agents for accurate HCC diagnosis. Future investigations may focus on refining imaging protocols, ultimately improving patient care and management decisions.