Quantification of Tau in the Piriform Cortex in AD using MR-PET
Motivation: Olfactory dysfunction can be an early sign of Alzheimer’s disease (AD), but involvement of primary olfactory piriform cortex in AD pathology is unknown. Goal(s): We use Tau MR-PET to compare piriform cortex uptake to the adjacent medial temporal lobe across the progression of AD pathology. Approach: Using PI-2620 Tau MR-PET, we manually segmented and computed piriform tau compared to automatically segmented medial temporal uptake in amyloid negative/positive healthy controls, mild cognitive impairment, and AD subjects. Results: Piriform tau uptake increases ordinally with disease severity and is significantly different higher in amyloid positive compared to negative controls. Impact: We show early increases in piriform cortex tau uptake that closely track adjacent medial temporal regions. This not only explains deficits in olfaction early in AD but opens the door to more sensitive testing and comprehensive detection of neurodegeneration.
Authors
- Michael Zeineh (ORCID: https://orcid.org/0000-0002-6940-9096)
- Marios Georgiadis (ORCID: https://orcid.org/0000-0003-0733-4559)
- Mahta Karimpoor (ORCID: https://orcid.org/0000-0001-8025-6230)
- Eric van Staalduinen
- America Romero
- Guido Davidzon (ORCID: https://orcid.org/0000-0001-5579-6825)
- Jarrett Rosenberg (ORCID: https://orcid.org/0000-0003-2706-3290)
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Mackenzie Carlson (ORCID: https://orcid.org/0000-0002-0857-3116)
- Greg Zaharchuk (ORCID: https://orcid.org/0000-0001-5781-8848)
- Hossein Moein Taghavi (ORCID: https://orcid.org/0000-0002-8585-1634)
- Alexandra N. Trelle (ORCID: https://orcid.org/0000-0003-2837-8753)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Victor W. Henderson (ORCID: https://orcid.org/0000-0003-1198-9240)
- Hillary Vossler
- Samantha Leventis
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3906
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00