A water relaxometry atlas for tissue correction of MRS data
Motivation: Water-referenced metabolite quantification in MRS often relies upon fixed water-relaxation reference times, ignoring differences in relaxation across the brain and lifespan. Goal(s): To develop a water relaxometry atlas to integrate location- and age-appropriate relaxation values into the MRS analysis workflow. Approach: DESPOT was used to collected quantitative T1 and T2 images in a cohort of 52 subjects aged 20-70 years old, and morphed to standard-space to generate a relaxometry aging atlas. We also perform a parcel-wise assessment of age-related relaxation changes. Results: The high-resolution water relaxometry aging atlas indicates significant changes in water relaxometry across the lifespan in many brain regions. Impact: Access to whole-brain relaxometry reference values, with appropriate consideration of aging, is vital to accurate water-referenced metabolite quantification in MRS.
Authors
- Kathleen E. Hupfeld (ORCID: https://orcid.org/0000-0001-5086-4841)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Aaron T. Gudmundson (ORCID: https://orcid.org/0000-0001-5104-0959)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Emily Carter
- Steve C. N. Hui (ORCID: https://orcid.org/0000-0002-1523-4040)
- Douglas Dean (ORCID: https://orcid.org/0000-0002-7057-1285)
- Can Ceritoglu (ORCID: https://orcid.org/0000-0001-6081-2551)
- Eric C. Porges (ORCID: https://orcid.org/0000-0003-3885-5859)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- J. Tilak Ratnanather (ORCID: https://orcid.org/0000-0002-8631-489X)
- Emlyn Muska
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4247
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00