Prediction of MGMT promotor methylation status in glioblastoma by contrast-enhanced T1-weighted intensity image
Motivation: Non-invasive prediction of GBM’s pMGMT methylation status is still challenging despite recent advancements of image analysis. Goal(s): This study explored a clinically feasible imaging biomarker that represents GBM’s pMGMT methylation status with external validation. Approach: Two qualitative imaging features, namely the “Thickened structure” and the “Methylated contrast phenotype,” were identified as valuable to this means. Results: GBMs presenting both imaging features exhibited a significantly high odds ratio, favoring pMGMT methylation in the exploratory and validation cohorts with a sensitivity and specificity of approximately 0.3-0.4 and 0.8. The easy clinical application of the proposed imaging features is expected to facilitate better preoperative GBM characterization. Impact: GBMs presenting both imaging features, namely the “Thickened structure” and the “Methylated contrast phenotype,” exhibited a significantly high odds ratio, favoring pMGMT methylation in the exploratory and validation cohorts with a sensitivity and specificity of approximately 0.3-0.4 and 0.8.
Authors
- Masahiro Nonaka (ORCID: https://orcid.org/0000-0002-8127-2635)
- Shusei Fukuyama
- Yonehiro Kanemura (ORCID: https://orcid.org/0000-0002-1894-1824)
- Mishie Ann Tanino (ORCID: https://orcid.org/0000-0003-3370-0452)
- Shota Yamamoto (ORCID: https://orcid.org/0000-0001-7706-7762)
- Seiya Fujikawa (ORCID: https://orcid.org/0000-0002-6614-1258)
- Koji Takano (ORCID: https://orcid.org/0000-0002-9200-9461)
- Tomoko Shofuda
- Daisuke Kanematsu
- Yoshinori Kodama (ORCID: https://orcid.org/0000-0002-7459-7984)
- Yoshiko Okita (ORCID: https://orcid.org/0000-0002-2943-238X)
- Takehiro Uda (ORCID: https://orcid.org/0000-0001-6422-4140)
- Ema Yoshioka
- Hideyuki Arita (ORCID: https://orcid.org/0000-0002-1126-8155)
- Manabu Kinoshita (ORCID: https://orcid.org/0000-0001-7923-6902)
- Junya Fukai (ORCID: https://orcid.org/0000-0001-7103-8493)
- Namiko Nishida (ORCID: https://orcid.org/0000-0001-9085-2394)
- Takahiro Sasaki (ORCID: https://orcid.org/0000-0002-0412-8760)
- Kenichi Ishibashi (ORCID: https://orcid.org/0000-0002-6216-1657)
- Takahiro Sanada (ORCID: https://orcid.org/0000-0001-6910-1959)
- Kanji Mori
- Nobuhide Hayashi
- Masayuki Mano
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3864
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.44