MRI Radiomics Enhances Radiologists' Ability for Characterizing Intestinal Fibrosis in Patients with Crohn's Disease

Motivation: Fibrostenosis is a severe complication of Crohn's disease that significantly impacts patients' quality of life. Currently, there are no effective medical interventions for severe intestinal fibrosisGoal(s): We aimed to develop MRI-based radiomic models to improve the diagnostic accuracy of radiologists in characterizing intestinal fibrosis in patients with Crohn’s disease.Approach: Radiomic models based on different MR sequence combinations were developed and validated in an independent test cohort. Results: The radiologists’ interpretation aided by MRI-radiomics outperformed visual interpretation in characterizing intestinal fibrosis in Crohn's disease (AUC=0.86-0.93 vs. AUC=0.63-0.77). Impact: The utilization of MRI-based radiomic models significantly enhances the diagnostic accuracy of radiologists in characterizing intestinal fibrosis.