Prediction of ATRX Gene Status in IDH-mutant grade 2/3 Gliomas by ADC and APT Histogram Analysis

Motivation: To the best of our knowledge, no study has explored the predictive ability of APT for ATRX mutations in gliomas. Goal(s): Investigating APT and ADC's predictive capacities for ATRX mutations in WHO grade 2/3 gliomas with IDH mutations, we conducted a retrospective analysis. Approach: We retrospectively analyzed data from these patients and extracted features for modeling. Results: The results revealed the APT-median became the key diagnostic parameter, and the model developed showed the highest diagnostic efficiency. The histogram analysis method based on APT and ADC is an effective non-invasive tool for predicting ATRX gene status. Impact: Our study, to our knowledge, pioneered the use of APT in predicting ATRX mutations in gliomas and established histogram analysis of APT and ADC as an effective non-invasive tool for ATRX gene prediction in IDH mutant WHO grade 2/3 gliomas.