Spatio-temporal Consistency Analysis of Cerebral Small Vessel Disease: A fMRI study

Motivation: Cerebral small vessel disease (SVD) affects older adults, but traditional approaches have limited understanding of the neural mechanisms of SVD. Goal(s): To explore the effects of SVD on brain regions and its relationship to cognitive decline by FOCA method. Approach: MRI data from 42 SVD patients and 38 controls were analyzed using FOCA values, and the correlation between FOCA values of SVD patients and SVD score was explored. Results: Different FOCA value changes in SVD patients were associated with regions of cognitive function. Impact: This study has the potential to improve our understanding of the neural mechanisms of SVD, suggesting that FOCA values provide a new method to analyzing changes in cognitive function.