Reproducibility assessment of multiparametric non-contrast cardiac MRI including ASL, T1 and T2 mapping in healthy controls

Motivation: Contrast-agent free techniques are needed in cardiac MRI studies for assessment of patients with coronary artery disease but with contraindications to gadolinium contrast-agents, such as kidney disease. Goal(s): The aim of this work was to assess the intra and intersession reproducibility of a multiparametric protocol including three non-contrast techniques (ASL, native T1 and T2 mapping) in healthy controls with a wide age range to eventually test the technique in clinical patients. Approach: Multiparametric non-contrast cardiac MRI in ten healthy controls at 1.5T. Results: This protocol can offer contrast free alternative for perfusion quantification, T1 and T2 mapping, with good intra and intersession reproducibility. Impact: Multiparametric cardiac MRI with arterial spin labelling (ASL) perfusion, T1 and T2 mapping could offer a contrast-agent free alternative for patients with kidney disease, or other contraindication to gadolinium agents, with good intra and intersession reproducibility.