Time-dependent diffusion-weighted MRI for pathological grade of clear cell renal cell carcinoma

Motivation: Accurate grading of clear cell renal cell carcinoma (ccRCC) is essential for treatment decisions, particularly in patients with comorbidities. Goal(s): This study aims to investigate time-dependent diffusion MRI to noninvasively characterize the microstructural properties of ccRCC and distinguish between different pathological grades. Approach: A total of 66 patients with histologically confirmed ccRCC underwent MRI scans, and microstructural parameters were estimated using time-dependent diffusion MRI techniques. Results: The study revealed distinct microstructural differences between low-grade and high-grade ccRCC, showing the potential of time-dependent diffusion MRI for preoperative pathological grade characterization. Impact: This study has the potential to reshape the landscape of preoperative ccRCC grading, promote objectivity in treatment planning.