Added Value of Electrical Conductivity Information to Apparent Diffusion Coefficient in Distinguishing Thoracic Lesions

Motivation: The electrical conductivity (σ) has been proven as helpful for glioma and breast cancer characterization. Our prior study also suggests its potential utility in distinguishing benign and malignant thoracic lesions. Goal(s): This study aimed to evaluate the added value of σ to thoracic lesion diagnosis by apparent diffusion coefficient (ADC). Approach: In this prospective study, we used radiomics analysis to evaluate the prediction value of ADC and σ. The diagnostic performance of selected ADC, σ, and composite indices were compared. Results: 7 independent features were identified in 21 lesions. Half of the top 4 features were from σ. All indices achieved excellent performance. Impact: The results of this preliminary study highlight the potential usefulness of noninvasive electrical conductivity (σ) measurement in the characterization of thoracic lesions.