Enhancing Diagnostic Precision in Clear Cell Renal Cell Carcinoma: A Comparative Analysis of ADC and CTRW Models

Motivation: The unexplored potential of applying the continuous-time random walk (CTRW) model for clear cell renal cell carcinoma (ccRCC) grading, possibly surpassing the effectiveness of apparent diffusion coefficient (ADC). Goal(s): To compare ADC and CTRW in diagnosing ccRCC grades via MRI. Approach: This study involved 52 ccRCC patients and employed in-house software for CTRW and ADC maps. Statistical analysis employed Mann-Whitney U tests and ROC curves. Results: DCTRW outperformed ADC in grading ccRCC, effectively distinguishing between low- and high-grade cases, while αCTRW and βCTRW did not. Impact: This research has the potential to shape clinical practices, offering more accurate ccRCC diagnoses, leading to better treatment decisions, and driving advancements in renal cell carcinoma research.