Development of an Ex-Vivo Porcine Model of the Bladder for 3D Dynamic MRI Validation

Motivation: Recently developed MRI-Urodynamics methods require rigorous validation. In vitro approaches have been implemented, however lack of tissue-like mechanical properties of the in models limits their applicability. Goal(s): Develop and implement an ex-vivo bladder model for validation of MRI-Urodynamics. Approach: Porcine bladder was obtained and connected to a syringe pump to conduct MRI experiments during filling and voiding at various flow-rates. Simultaneous pressure measurements were performed during MRI. Results: Ex-vivo bladder MRI experiments were successfully conducted. MRI-derived flow-rates agree within 10% when compared to the flow-rates imposed by the syringe pump. Pressure-volume analysis provided means of comparison of bladder performance between filling and voiding. Impact: 3D dynamic MRI can assess anatomical changes in the bladder during voiding and filling. Systematic validation of this technique can enhance its clinical use.