Technical Considerations for Implementing Multi-Center and Multi-Platform Quantitative DCE-MRI to Predict Breast Cancer Therapy Response
Motivation: Determine best-practice quantitative DCE-MRI for predicting breast cancer (BC) response to neoadjuvant chemotherapy (NAC) in a multi-center (MC) and multi-vendor platform (MP) setting. Goal(s): Evaluate effects of different pharmacokinetic analysis approaches on Ktrans and its predictive performance. Approach: 15 BC patients treated with NAC underwent longitudinal DCE-MRI at 3 sites using 3T systems from 3 vendors. Variations in analysis included Tofts model vs. Shutter-Speed model (SSM), ROI- vs. voxel-based analysis, and using fixed vs. measured R10. Results: Different analysis approaches resulted in significantly different Ktrans, with SSM Ktrans from voxel-based analysis using fixed R10 showing highest predictive accuracy for response. Impact: Voxel-based SSM analysis using fixed R10 takes advantage of greater range of SSM Ktrans changes in response to therapy, mitigates R10 measurement errors, and may be the best-practice quantitative DCE-MRI for predicting NAC response in a MC and MP setting.
Authors
- Evthokia Hobbs (ORCID: https://orcid.org/0000-0002-7738-0131)
- Debosmita Biswas (ORCID: https://orcid.org/0000-0002-0798-5637)
- Savannah C. Partridge (ORCID: https://orcid.org/0000-0001-6370-9111)
- Su Kim (ORCID: https://orcid.org/0000-0002-2645-2844)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Suzanne M. Dintzis (ORCID: https://orcid.org/0000-0001-9762-030X)
- Anum S. Kazerouni (ORCID: https://orcid.org/0000-0002-4200-534X)
- Michael Hirano
- Habib Rahbar (ORCID: https://orcid.org/0000-0003-4835-1478)
- Christian Wille
- Mary Lynn Bryant
- James H. Holmes (ORCID: https://orcid.org/0000-0002-0936-3700)
- Travis Rice‐Stitt
- Chelsea Pyle
- Isabella Li
- Sneha Phadke (ORCID: https://orcid.org/0000-0002-9829-1066)
- Alexandra S. Zimmer (ORCID: https://orcid.org/0000-0001-6789-0982)
- Nicole Margo Grogan Fleege (ORCID: https://orcid.org/0000-0001-9268-7070)
- Amani Bashir (ORCID: https://orcid.org/0000-0002-7239-3662)
- Alina Tudorica
- Assim Saad Eddin (ORCID: https://orcid.org/0009-0000-8769-7311)
- Xin Li (ORCID: https://orcid.org/0000-0002-2949-5663)
- Wei Huang (ORCID: https://orcid.org/0000-0002-3468-7467)
- Brendan Moloney
- Jeong Youn Lim
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1167
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00