Altered Volumes of the Limbic Structures in COVID-19 Patients with neuroPASC revealed by Ultrahigh Field 7T MRI
Motivation: Post-Acute Sequelae of COVID-19 of neurological origin (neuroPASC), such as brain fog and anxiety, are not well understood. Goal(s): To study volumetric changes in the brain’s limbic structures in COVID-19 patients with neuroPASC such as brain fog. Approach: 29 COVID-19 patients with neuroPASC and 29 matched controls underwent ultrahigh field brain MRI at 7T. Hippocampal subfields and amygdala subnuclei were segmented with FreeSurfer and studied across neuroPASC subgroups. Results: Several subunit volumes were significantly decreased in COVID patients compared to controls across neuroPASC subgroups. Sex-based differences were also present. Impact: There may be subtle changes in the volumes of the brain’s limbic structures in COVID patients with neuroPASC compared to controls. These changes may be related to neuroPASC symptoms and may depend on sex differences.
Authors
- Oleksandr Khegai
- Claudia Kirsch (ORCID: https://orcid.org/0000-0002-4978-4198)
- Sera Saju
- Puneet Pawha (ORCID: https://orcid.org/0000-0002-8239-3308)
- Alan C. Seifert (ORCID: https://orcid.org/0000-0001-7877-4813)
- Priti Balchandani (ORCID: https://orcid.org/0000-0001-7709-5835)
- Puneet Belani
- Nathalie Jetté (ORCID: https://orcid.org/0000-0003-1351-5866)
- Jacqueline Becker (ORCID: https://orcid.org/0000-0003-2708-6046)
- Bradley N. Delman (ORCID: https://orcid.org/0000-0002-9792-8942)
- Shams Rashid (ORCID: https://orcid.org/0009-0009-4779-7305)
- Yijuan Zhu
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2079
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00