DCE-MRI Tumor Volumetric Changes Predict Response to Neoadjuvant Immunochemotherapy in Triple Negative Breast Cancer Patients
Motivation: There is unmet need for noninvasive biomarkers for neoadjuvant immunochemotherapy (NICT) response prediction in triple negative breast cancer (TNBC) to guide least toxic and most effective treatment regimens. Goal(s): To evaluate if DCE-MRI tumor volume changes measured early during NICT can predict treatment response. Approach: DCE-MRI tumor volume reduction (TVR) was calculated in 64 TNBC at baseline, after 2 and 4 cycles of NICT and correlated with surgical pathology using ROC analysis. Results: DCE-MRI TVR after 2 cycles of NICT was able to predict pCR with AUC of 0.71 (95%CI:0.57-0.84) and after 4 cycles with AUC of 0.81 (95%CI:0.69-0.92). Impact: DCE-MRI tumor volume changes early during neoadjuvant immunochemotherapy can identify triple negative breast cancer patients with high/low likelihood of pathologic complete response, triaging them to appropriate management for de-escalation trials versus targeted therapies, avoiding unnecessary toxicity of ineffective treatment.
Authors
- Gary J. Whitman (ORCID: https://orcid.org/0000-0003-2002-7457)
- Ken‐Pin Hwang (ORCID: https://orcid.org/0000-0002-8196-3794)
- Marion E. Scoggins (ORCID: https://orcid.org/0000-0002-4822-9512)
- Frances Perez (ORCID: https://orcid.org/0000-0002-4919-1843)
- Rania M. Mohamed (ORCID: https://orcid.org/0000-0002-6487-3965)
- Gaiane M. Rauch
- Miral Patel (ORCID: https://orcid.org/0000-0002-0942-2731)
- Deanna L. Lane (ORCID: https://orcid.org/0000-0001-8221-4333)
- Sanaz Pashapoor
- Jong Bum Son (ORCID: https://orcid.org/0000-0003-2548-5895)
- Mary S. Guirguis (ORCID: https://orcid.org/0000-0001-5874-8861)
- Clinton Yam (ORCID: https://orcid.org/0000-0002-0809-0851)
- Rosalind P. Candelaria (ORCID: https://orcid.org/0000-0002-7897-7896)
- Tanya W. Moseley (ORCID: https://orcid.org/0000-0002-2018-8253)
- Jessica Leung (ORCID: https://orcid.org/0000-0002-5164-7555)
- Beatriz E. Adrada (ORCID: https://orcid.org/0000-0002-5539-5332)
- Zhan Xu (ORCID: https://orcid.org/0000-0002-5892-0227)
- Huong T. Le‐Petross (ORCID: https://orcid.org/0000-0003-0356-498X)
- Wei Peng (ORCID: https://orcid.org/0000-0002-4166-2014)
- Wei Yang (ORCID: https://orcid.org/0000-0003-2936-2972)
- Jingfei Ma (ORCID: https://orcid.org/0000-0003-2827-8891)
- Jia Sun (ORCID: https://orcid.org/0000-0002-1303-4803)
- Huiqin Chen (ORCID: https://orcid.org/0000-0003-2477-5436)
- Debu Tripathy (ORCID: https://orcid.org/0000-0002-5711-2404)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4604
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00