Assessment of repeatability and reproducibility of brain oxygen extraction fraction mapping through QQ-CCTV

Motivation: QQ-CCTV has been validated under 3T to map brain oxygen extraction fraction. Yet its repeatability and reproducibility has not been evaluated under 1.5T. Goal(s): Assess the repeatability and reproducibility of QQ-CCTVApproach: QQ-CCTV was performed to calculate brain oxygen extraction from repeated scans under 3T and 1.5T. OEF values are compared between scans using linear regression and Bland-Altman plots. Results: The OEF values obtained from 3T and 1.5T scans show minimal bias and good correlation. Although under 1.5T the sampled data have lower SNR, QQ-CCTV may benefit from lower characteristic frequency and longer characteristic time. Impact: QQ-CCTV can be used with mGRE data acquired under 1.5T to map brain oxygen extraction with good repeatability and reproducibility and has the potential to be used clinically.