Higher oxygen extraction fraction in coronary artery disease is associated with lower cognition and cardiorespiratory fitness in males.
Motivation: There is a lack of knowledge about the physiological underpinnings of the effects of coronary artery disease (CAD) on human brain health. Goal(s): Here we investigated the effect of CAD on brain oxygen extraction fraction (OEF) Approach: Using quantitative susceptibility mapping (QSM) and its relation to cognitive performance and cardiorespiratory fitness. Results: The results of the sex-disaggregated analysis in a preliminary dataset show that CAD male patients have significantly higher OEF in whole gray matter, frontal, occipital, and temporal lobes. Furthermore, higher OEF in males is associated with lower cognitive performance, and higher OEF is associated with lower VO2max. Impact: Sex differences in the effects of coronary artery disease (CAD) on brain health are unknown. Our results show that CAD increases OEF, and that higher OEF is associated with lower cognitive performance , and lower cardiorespiratory fitness in males.
Authors
- Dalia Sabra
- Anil Nigam (ORCID: https://orcid.org/0000-0002-0253-7990)
- Brittany Intzandt (ORCID: https://orcid.org/0000-0001-8475-988X)
- Stefanie A Tremblay (ORCID: https://orcid.org/0000-0001-6026-6239)
- Thomas Vincent (ORCID: https://orcid.org/0000-0001-6202-1585)
- Dajana Vuckovic (ORCID: https://orcid.org/0000-0002-7764-8492)
- Julia Huck (ORCID: https://orcid.org/0000-0002-5701-8506)
- Mathieu Gayda (ORCID: https://orcid.org/0000-0003-1721-2299)
- Safa Sanami
- Claudine Joëlle Gauthier (ORCID: https://orcid.org/0000-0002-5137-5019)
- Josep Iglésies (ORCID: https://orcid.org/0000-0003-3269-6455)
- Lindsay Wright (ORCID: https://orcid.org/0000-0003-4739-883X)
- Amélie Mainville-Berthiaume
- Zacharie Potvin-Jutras (ORCID: https://orcid.org/0009-0003-9656-2728)
- C. Gagnon
- Ali Rezaei
- Louis Bherer
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1778
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00