Correlation analysis of the behavioral analysis and quantitative T2 map data in the SOD1G93A mouse model

Motivation: Amyotrophic lateral sclerosis is still an understudied disease, and early detection is important. Goal(s): This study aimed to clarify the transition of the pathophysiology and evaluate the relationship between the abnormalities detected on magnetic resonance imaging and the development of clinical symptoms by combining the T2 map data obtained in the previous study with behavioral analysis. Approach: Behavioral analysis was performed on four parameters, namely, bodyweight, general condition, hind-foot reflex test, and landing foot-splay test. Correlation analysis of the behavioral analysis data and T2 map data was performed in each voxel. Results: A correlation was detected in the trigeminal motor nucleus. Impact: Changes in the trigeminal motor nucleus are indicated to be closely related to early changes in amyotrophic lateral sclerosis (ALS). This finding is suggested to be useful for the early diagnosis of ALS in humans and research on novel treatments.