Discrepancies between Magnetic Resonance Fingerprinting and other T1 and T2 mapping methods are microstructure dependent
Motivation: T1 and T2 accuracy in the brain is difficult to assess, since there is no ground truth available. Goal(s): To investigate how well relaxometry methods agree. Approach: We compare Magnetic Resonance Fingerprinting (MRF) T1 and T2 mapping with Variable Flip Angle (VFA) T1 mapping and Multi-Echo Spin Echo (T2) mapping in 11 anatomical brain regions for 10 healthy volunteers, and in the relevant spheres of the NIST phantom. Results: MRF underestimates T1 and T2 in comparison with T1 VFA and T2 MESE in the human brain, especially in myelin-dense areas. Less T1 and no T2 bias is present in the NIST phantom. Impact: Quantitative T1 and T2 relaxometry techniques are more consistent in the NIST phantom than the human brain. Deviations could be caused by magnetisation transfer, whose impact on T1 and T2 relaxation mechanisms needs further investigation.
Authors
- Stefanie Thust (ORCID: https://orcid.org/0000-0001-5136-6000)
- Rebecca Quest (ORCID: https://orcid.org/0000-0002-0457-8665)
- Iulius Dragonu
- Peter Lally (ORCID: https://orcid.org/0000-0003-0075-0103)
- Matthew Orton (ORCID: https://orcid.org/0000-0002-0805-763X)
- Simran Kukran
- Mary E. Finnegan (ORCID: https://orcid.org/0000-0001-5655-0886)
- Ben K. Statton (ORCID: https://orcid.org/0000-0001-5118-7977)
- Dow‐Mu Koh (ORCID: https://orcid.org/0000-0001-7654-8011)
- Servando Cardona
- Matthew Grech‐Sollars (ORCID: https://orcid.org/0000-0003-3881-4870)
- Luke Dixon (ORCID: https://orcid.org/0000-0003-4060-7897)
- Joely Smith (ORCID: https://orcid.org/0000-0002-2382-4219)
- Neal K. Bangerter (ORCID: https://orcid.org/0000-0001-6444-1882)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2178
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00