Edited MRS of Glutamate

Motivation: Spectral editing methods are widely used to measure γ-aminobutyric acid (GABA), which also co-edits glutamate (Glu) at 2.34 ppm in the sum spectrum (sum=ON+OFF). However, the co-detection of Glu at 2.34 ppm has not been assessed. Goal(s): We demonstrate the co-editing of Glu without glutamine using HERMES of GABA and glutathione. Approach: Simulations of HERMES and 1D J-resolved of Glu, glutamine, and GABA, followed by in vivo experiments on 137 participants. Results: Simulations and in vivo experiments show a Glu-edited signal without overlapping glutamine and GABA signals from both methods. In vivo quantification of Glu show that the two methods are significantly correlated. Impact: Our study demonstrates a purer measurement of Glu using HERMES without needing a separate acquisition. HERMES provides an opportunity to study Glu/GABA/glutathione concurrently to understand their relationships under homeostasis or drug interventions that might affect the glutamatergic/GABAergic/antioxidant systems.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/4253
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
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article

Edited MRS of Glutamate

Deborah Yurgelun‐Todd, Muhammad G. Saleh, Eric P. Cunningham, Helge J. Zöllner et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced MRI Techniques and Applications
article

Edited MRS of Glutamate

Deborah Yurgelun‐Todd, Muhammad G. Saleh, Eric P. Cunningham, Helge J. Zöllner, Christine Cloak, Richard A.E. Edden, Timothy P. L. Roberts, Punitha Subramaniam, Perry F. Renshaw, Linda Chang, Andrew P. Prescot, Thomas Ernst
article en

Abstract

Motivation: Spectral editing methods are widely used to measure γ-aminobutyric acid (GABA), which also co-edits glutamate (Glu) at 2.34 ppm in the sum spectrum (sum=ON+OFF). However, the co-detection of Glu at 2.34 ppm has not been assessed. Goal(s): We demonstrate the co-editing of Glu without glutamine using HERMES of GABA and glutathione. Approach: Simulations of HERMES and 1D J-resolved of Glu, glutamine, and GABA, followed by in vivo experiments on 137 participants. Results: Simulations and in vivo experiments show a Glu-edited signal without overlapping glutamine and GABA signals from both methods. In vivo quantification of Glu show that the two methods are significantly correlated. Impact: Our study demonstrates a purer measurement of Glu using HERMES without needing a separate acquisition. HERMES provides an opportunity to study Glu/GABA/glutathione concurrently to understand their relationships under homeostasis or drug interventions that might affect the glutamatergic/GABAergic/antioxidant systems.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
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Openalex Percentile: Top 64%
Advanced MRI Techniques and Applications
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Edited MRS of Glutamate — Deborah Yurgelun‐Todd, Muhammad G. Saleh, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024) | TGRS Research Map | TGRS