The association between the intravoxel incoherent motion diffusion-weighted imaging(IVIM) with the DSC and 3DASL imaging in Glioma Recurrence

Motivation: Diffusion-weighted imaging and perfusion-weighted imaging have shown promising accuracy in differentiating glioma recurrence and treatment-related changes. Intravoxel incoherent motion (IVIM) MRI enables the simultaneous acquisition of diffusion and perfusion parameters, providing true diffusion and capillary perfusion in the tumor. Goal(s): To evaluate the diagnostic performance of IVIM-derived parameters in glioma recurrence patients with DSC and 3DASL perfusion-weighted imaging. Approach: The correlation between IVIM parameter and perfusion-MRI parameters was evaluated in regions of contrast enhancement with Pearson’s correlation analysis. Results: ADC-F within T1-enhanced lesions positively correlated with relative cerebral blood volume (rCBV),nrCBF, and nCBF. Additionally,ADC-F was statistically significantly associated with rCBV and nrCBF. Impact: IVIM has the same diagnostic efficacy for recurrent glioma with the perfusion-MRI parameters and can used as a reliable alternative diagnostic sequence for glioma recurrence.