Association of pulmonary transit time by CMR with diastolic dysfunction and left ventricle deformation in restrictive cardiomyopathy

Motivation: Cardiopulmonary circulation usually present hemodynamic congestion in RCM patients. Pulmonary transit time (PTT) and pulmonary blood volume index (PBVi) are physiological parameters reflective of cardiopulmonary hemodynamics statue. Goal(s): Evaluate the PTT and PBVi in RCM patients, and evaluated the association with LV function and deformation. Approach: The images of first-pass perfusion were acquired to assess PTT which was normalized to heart rate. PBVi was measured by the product of PTT and RVSV and indexed to BSA. Results: PTT showed independent association with LVEF and LVMVR, as well as with LV GCPS and GLPS; PBVi was an independent association of LVMI and LV GRPS. Impact: PTTc and PBVi as the non-invasive marker of cardiopulmonary hemodynamics in patients with RCM, and reflects progression of diastolic dysfunction, and impaired LV global deformation. PTT and PBVI may provide additional information for prognostic management and clinical decision making.