The feasibility study of multiple functional imaging modalities in the differential diagnosis of benign and malignant bone tumors

Motivation: The combination of multi-MRI techniques in the differential diagnosis of benign and malignant bone tumors represents a novel endeavor. Goal(s): To investigate the utility of combining DWI, IVIM, DKI and APTWI in the differential diagnosis of benign and malignant bone tumors. Approach: Relevant parameters of 45 patients were statistically compared through either the independent samples t-test or Mann-Whitney U test. Diagnostic performance was assessed using ROC curves for both individual examinations and their combined analysis in distinguishing between benign and malignant tumors. Results: The combination of multi-MRI techniques proves to be a more effective approach in distinguishing between benign and malignant bone tumors. Impact: Multimodal MRI provides biological and pathological information about the tumor cell microenvironment, and their combination proves to be a more effective approach in distinguishing between benign and malignant bone tumors.