A Novel PET/MRI Hybrid Probe enables Non-invasive Imaging of Perfusion and Excretion in vivo

Motivation: Our work is driven by the conviction that the integration of PET and MRI in molecular imaging has the potential to revolutionize diagnostic precision and patient care. Goal(s): Enhance precision molecular imaging through the development of a unique hybrid PET/MRI perfusion probe, [18F][Gd(FL1­­)]. Approach: Develop a PET/MRI probe, [18F][Gd(FL1­­)], that is exceptionally stable, rapidly synthesized, efficiently radiolabeled, and allows simultaneous PET/MR imaging, focusing on tissue perfusion and renal filtration in preclinical models. Results: After achieving high-yield radiosynthesis with a unique approach, our dual-modality probe showed consistent signals in both imaging modalities and was reliably quantified thanks to the combination of PET and MRI. Impact: The first-of-its-kind hybrid PET/MR probe [18F][Gd(FL1­­)] can be readily and efficiently radio-synthetized and allows simultaneous PET/MR quantitative measurement of perfusion and excretion. This probe opens the path for quantifying molecular imaging probes in research and clinical practice.