Application of Time-dependent Diffusion MRI for Evaluation of Differentiation Grades in Cervical Squamous Cell Carcinoma

Motivation: Differentiation grade is an important pathological risk factor associated with metastasis and prognosis in cervical cancer. Our study aimed to investigate the possibility of using OGSE to evaluate differentiation grades in cervical squamous cell carcinoma (CSCC) before treatment. Goal(s): The primary goal is to investigate the feasibility of evaluating differentiation grades in CSCC with OGSE, aiming to enhance diagnostic precision and prognostic insights. Approach: Through an innovative OGSE method, this study explores key parameters for assessing differentiation grades in CSCC, contributing to noninvasive diagnostic methodologies. Results: The study reveals significant differences in cellularity and fin between well/moderately and poorly differentiated CSCC grades. Impact: This time-dependent diffusion approach provides a new direction for noninvasively differentiating grades in CSCC.