In vivo assessment of astrocyte reactivity in patients with progressive supranuclear palsy
Motivation: Although astrocytic pathology is a pathological hallmark of progressive supranuclear palsy (PSP), the role of astrocytes in the pathophysiology of PSP is not fully understood. Goal(s): This study aimed to evaluate astrocyte reactivity in vivo in patients with PSP. Approach: Astrocyte reactivity was assessed by magnetic resonance spectroscopy and plasma biomarkers, which were verified via tau-PET and histopathological analysis. Results: Our results suggest that, in the anterior cingulate cortex, astrocyte reactivity precedes pronounced tau deposition and neurodegenerative processes and modulates brain function in PSP. Elevated myo-inositol was associated with high lactate levels, suggesting a link between reactive astrocytes and brain energy metabolism changes. Impact: This study assessed astrocyte reactivity in vivo using magnetic resonance spectroscopy and plasma biomarkers, providing insights into the involvement of astrocytes in the pathogenesis of progressive supranuclear palsy.
Authors
- Maiko Ono
- Masoumeh Dehghani (ORCID: https://orcid.org/0000-0003-2494-2724)
- Keisuke Takahata (ORCID: https://orcid.org/0000-0002-0884-4924)
- Hironobu Endo
- Hiroshi Shimizu (ORCID: https://orcid.org/0000-0002-4869-502X)
- Jamie Near (ORCID: https://orcid.org/0000-0003-3516-936X)
- Naomi Kokubo (ORCID: https://orcid.org/0000-0002-6904-9107)
- Makoto Higuchi (ORCID: https://orcid.org/0000-0002-9190-7235)
- Yuko Kataoka (ORCID: https://orcid.org/0000-0001-7584-1005)
- Asaka Oyama
- Yuhei Takado (ORCID: https://orcid.org/0000-0001-7484-8424)
- Takayuki Obata (ORCID: https://orcid.org/0000-0001-7678-5033)
- Kiwamu Matsuoka (ORCID: https://orcid.org/0000-0003-3263-0958)
- Hitoshi Shinoto
- Kosei Hirata (ORCID: https://orcid.org/0009-0007-9027-9277)
- Hitoshi Shimada (ORCID: https://orcid.org/0000-0002-7139-7178)
- Harutsugu Tatebe
- Kenji Tagai (ORCID: https://orcid.org/0000-0002-4551-1491)
- Takahiko Tokuda (ORCID: https://orcid.org/0000-0002-7411-4911)
- Takanori Yokota (ORCID: https://orcid.org/0009-0001-6645-9397)
- K Kawamura
- Ming-Rong Zhang
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1048
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00