Longitudinal brain age is informative of future executive function in Asian children and elderly
Motivation: Brain age models have not been well-tested in non-Caucasian populations or longitudinally. Goal(s): We aimed to determine whether brain age models generalize to an Asian population and whether longitudinal changes in brain age associate with future cognition. Approach: We applied a pretrained brain age model to Singaporean elderly and children, compared our results after finetuning the model, and examined cross-sectional and longitudinal associations with cognition. Results: The model could be directly applied to elderly, but finetuning was necessary for children. The longitudinal change in brain age gap significantly associated with future executive function performance in both elderly and children. Impact: We show that there is real potential for generalizing brain age models to diverse populations, and that the longitudinal change in brain age contains additional information about future executive function, compared to baseline brain age.
Authors
- B.T. Thomas Yeo (ORCID: https://orcid.org/0000-0002-0119-3276)
- Wan Lin Yue (ORCID: https://orcid.org/0000-0003-3021-1418)
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Kim‐Ngan Nguyen (ORCID: https://orcid.org/0009-0004-5968-6307)
- Juan Helen Zhou (ORCID: https://orcid.org/0000-0002-0180-8648)
- Michael J. Meaney (ORCID: https://orcid.org/0000-0002-8605-1997)
- Siwei Liu (ORCID: https://orcid.org/0000-0003-1277-484X)
- Ruth L F Leong (ORCID: https://orcid.org/0000-0001-5567-2152)
- Xing Qian (ORCID: https://orcid.org/0000-0002-6653-7121)
- Kwun Kei Ng (ORCID: https://orcid.org/0000-0002-0584-7679)
- Evelyn Law (ORCID: https://orcid.org/0000-0003-4683-7220)
- Michael W.L. Chee (ORCID: https://orcid.org/0000-0002-6087-0548)
- Susan Cheng
- Trevor WK Tan
- Peter Gluckman
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3867
- Primary Topic
- Cognitive Abilities and Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00