Multicenter Harmonization of Longitudinal DTI and NODDI of White Matter Microstructure after Acute TBI: A TRACK-TBI* Study
Motivation: Diffusion MRI-derived NODDI demonstrated promise as biomarkers of post-TBI long-term symptoms and clinical outcomes in single-center studies, but hasn't been validated in large-scale multi-center trials. Goal(s): This study aimed to detect post-TBI white matter degeneration and its significance to outcomes using analysis methods incorporating RISH-based harmonization, followed by DTI and NODDI fitting. Approach: Harmonized DTI and NODDI are analyzed for a longitudinal comparison between 2 weeks and 6 months post-TBI, and for associations with GOSE, RPQ, and WAIS-PSI outcomes. Results: Widespread white matter degeneration was evident in longitudinal changes of DTI and NODDI. The 2-week metrics were predictive of 3 and 6-month outcomes. Impact: This study applies RISH-based harmonization to a multi-shell, multi-center dMRI study that involved 7 scanners of different manufacturers and models with different software versions and pulse-sequence parameters. These efforts brought new insights into post-traumatic white matter injury and patient outcomes.
Authors
- David O. Okonkwo (ORCID: https://orcid.org/0000-0002-7444-2851)
- Michael McCrea (ORCID: https://orcid.org/0000-0001-9791-9475)
- Amy J. Markowitz (ORCID: https://orcid.org/0000-0001-9314-2814)
- Ioanna Bourla
- Nancy Temkin (ORCID: https://orcid.org/0000-0002-6392-5292)
- Ramon Diaz‐Arrastia (ORCID: https://orcid.org/0000-0001-6051-3594)
- Sonia Jain (ORCID: https://orcid.org/0000-0001-8408-1247)
- Pratik Mukherjee (ORCID: https://orcid.org/0000-0001-7473-7409)
- Esther L. Yuh (ORCID: https://orcid.org/0000-0002-1180-2274)
- Joseph T. Giacino (ORCID: https://orcid.org/0000-0002-7916-9698)
- Jamie Wren-Jarvis (ORCID: https://orcid.org/0000-0001-6918-8599)
- Jaclyn Xiao (ORCID: https://orcid.org/0009-0001-5958-8465)
- Amir Sadikov
- Claudia Sue Robertson (ORCID: https://orcid.org/0000-0002-8509-678X)
- Murray B. Stein (ORCID: https://orcid.org/0000-0001-9564-2871)
- Geoffrey A. Manley (ORCID: https://orcid.org/0000-0002-4950-4651)
- Lanya T. Cai (ORCID: https://orcid.org/0000-0001-6750-6506)
- Xiaoying Sun (ORCID: https://orcid.org/0000-0001-9672-8554)
- Christine Mac Donald
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1610
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00