Whole Brain Coverage Multi-Target Framework for Benchmarking RF Arrays Tailored for Thermal Magnetic Resonance of Glioblastoma Multiforme

Motivation: Thermal Magnetic Resonance (ThermalMR) adds a thermal intervention dimension to MRI by focusing E-fields in the target region (TR). Today’s assessment of RF applicators uses TRs covering a few specific but arbitrary locations in the brain. This approach does not represent the full clinical picture. Goal(s): This work introduces a multi-target evaluation (MTE) framework and expands RF applicator evaluation to whole brain coverage. Approach: MTE using EMF simulations for a helmet and for an annular RF applicator. Results: Our MTE approach provides a technical foundation for the development and objective evaluation of RF applicators tailored for ThermalMR. Impact: MTE provides a technical foundation for objective RF applicator evaluation using whole brain coverage instead of a few specific but arbitrary target locations. Our framework presents a springboard for RF applicator design and for ThermalMR-based therapy of glioblastoma multiforme.