A continuous-time random-walk diffusion model for predicting tumor consistency and extent of resection in patients with pituitary adenomas

Motivation: Preoperative evaluation of the consistency of pituitary adenomas (PAs) plays a significant role in the surgical strategy. However, previous studies concerning the assessment of tumor consistency of PAs were controversial1-4. Goal(s): To evaluate the ability of the continuous-time random-walk (CTRW) diffusion model to predict the consistency and extent of resection (EOR) of PAs. Approach: The CTRW diffusion model relaxes a priori distributions of waiting times and distance increments of water molecular diffusion, providing a realistic description of the complex structures of biological tissues5. Results: CTRW diffusion model could provide information about the tumor consistency and EOR of PAs. Impact: CTRW diffusion model provides an imaging dimension for characterizing tissue microstructure of PAs and may serve as a promising tool to predict the tumor consistency and EOR in patients with PAs.