Analysis of the Myocardial Transit-time (MyoTT) between normal subjects and hypertrophic cardiomyopathy patients from a single center in China

Motivation: Myocardial microvascular disease is widespread in cardiovascular disease and is associated with an increased risk of adverse events. MyoTT, as a relatively novel, non-invasive, and easy-to-perform CMR parameter, played an important role in the diagnosis of disease. Goal(s): The study aims to observe the differences in myocardial microcirculation time between normal subjects and HCM patients. Approach: In this study, the CMR resting-state first-pass perfusion imaging sequence was used to measure the change of signal intensities from the coronary ostium to the coronary sinus to calculate the blood circulation time. Results: Patients with HCM had a significantly prolonged MyoTT compared to controlsImpact: MyoTT could be easily added to current CMR protocols and does not prolong CMR scan time. And future studies are required to evaluate the diagnostic as well as prognostic value of MyoTT in different cardiovascular diseases.