Transcriptional and Cellular Decoding of Cortical Morphometric Changes in Chronic Insomnia Disorder

Motivation: Chronic Insomnia Disorder (CID) influences various levels of brain organization, spanning macroscopic structures to microscopic genomics, the connection between genomic variations and structural brain alterations in CID was not clear. Goal(s): This study analyzed structural brain alterations-related genomes in CID. Approach: Using and morphometric similarity (MS) and imaging-transcription alanalysisResults: The study identified MS reductions in the parietal and limbic regions, as well as enhancements in the temporal and frontal regions in CID patients. The study also discovered spatial correlations between MS alterations and genes associated with excitatory and inhibitory neurons, as well as genes implicated in chronic neuroinflammation processes. Impact: This study bridges the gap between cortical structural changes and the molecular mechanisms in Chronic Insomnia Disorder (CID), shedding light on the genetic basis and brain alterations associated with CID.