Cerebrovascular Flow and White Matter Microstructural Integrity in the Presence of Amyloid and Tau Biomarkers

Motivation: This study is driven by the need to understand the intricate relationship between cerebrovascular disease (CVD) and Alzheimer's disease (AD) pathology. Goal(s): In this study, we aim to investigate the correlations between CVD markers, AD biomarkers and white matter (WM) microstructure. Approach: To achieve these goals, we used 4D flow MRI and neurite orientation dispersion and density imaging (NODDI) and utilized statistical models to examine the relationships between vascular flow and WM neurite density index. Results: Our results identified significant correlations between AD biomarkers, WM integrity and cerebrovascular flow in specific vessels. Impact: Our findings motivate further investigations into the intricate relationship between cerebrovascular disease and Alzheimer's disease (AD) pathology. Better understanding of this relationship may improve early AD detection and therapeutic strategies.