Discriminating High-Grade and Low-Grade Pediatric Gliomas by time-dependent diffusion MRI

Motivation: Gliomas are the most common type of central nervous system tumors in children, and the histological classification plays a crucial role in determining the prognosis and the treatment. A non-invasive approach is needed for pre-surgery characterization of the histopathology of the tumor. Goal(s): The aim of this study was to explore the feasibility of applying time-dependent diffusion magnetic resonance imaging (td-dMRI) parameters in discriminating between high-grade gliomas (HGG) and low-grade gliomas (LGG). Approach: Nine pediatric glioma patients were involved and underwent td-dMRI scan. Results: The td-dMRI parameters may serve as potential markers for the differentiation between high-grade gliomas (HGG) and low-grade gliomas (LGG). Impact: Time-dependent diffusion MRI parameters can distinguish pediatric high-grade and low-grade gliomas noninvasively, aiding personalized treatment and enhancing prognosis, among other potential applications.