Reproducibility of Whole-Brain Cerebral Blood Flow measurements using phase contrast and arterial spin labeling MRI

Motivation: We investigated the reproducibility of cerebral blood flow (CBF) measurement techniques with phase contrast (PC) and arterial spin labeling (ASL) MRI given their importance in diagnosing cerebrovascular diseases. Goal(s): Demonstrate the reproducibility of phase contrast and arterial spin labeling MRI techniques for measuring CBF. Approach: We used comparative analysis of CBF measurements using phase contrast and arterial spin labeling pre- and post- diamox vasodilation test, measured twice by a week apart. Results: Strong interclass correlation across modalities and sessions, indicating strong reproducibility for both techniques. Impact: We conclude that PC- and ASL- MRI measurements are in good agreement and have strong inter-session reproducibility in measuring CBF before and after vasodilation.