Biventricular intraventricular mechanical dyssynchrony and electronical dyssynchrony in pulmonary arterial hypertension

Motivation: The ability of layer-specific intraventricular mechanical dyssynchrony (M-dys) to predict prognosis in pulmonary arterial hypertension (PAH) has not been investigated. Goal(s): To illustrate the existence and prognostic values of layer-specific intraventricular M-dys and its associations with electronical dyssynchrony in PAH. Approach: The biventricular volumetric and layer-specific intraventricular M-dys were analyzed by calculating strain and strain rate based on cine cardiac magnetic resonance images. Results: The layer-specific intraventricular M-dys had varying impacts on biventricular functions in PAH. Impact: This study was novel in reporting that the layer-specific intraventricular M-dys had various distribution patterns in both ventricles in patients with PAH.