MRI-based methods for measuring foot perfusion

Motivation: For patients with peripheral artery disease knowing the perfusion in different areas of the foot might have clinical relevance when treating ischemia. Goal(s): The aim was to measure the reliability of five different MR sequences with quantitative parameters for measuring perfusion when imaging the foot.Approach: We used a cuff induced ischemia protocol in a test/retest study of 16 healthy volunteers Results: Flow-sensitive Alternating Inversion Recovery pulsed arterial spin labelling (FAIR) and Blood Oxygenation Level-Dependent (BOLD) sequences had high reliability and were able to distinguish between occluded blood flow and hyperactive response flowImpact: Reliability test of five different MR sequences for quantitative perfusion measurements in the foot.