Association of peripheral inflammation with disrupted brain functional network topology in bipolar disorder

Motivation: Increasing evidences show that inflammation might be involved in bipolar disorder (BD), but the association between abnormal brain function and inflammation in BD patients is still unclear. Goal(s): In this study, we tried to explore the disrupted brain functional network topology, peripheral cytokines and their correlations to demonstrate the role of inflammation in brain functional network topology in BD. Approach: Graph theory analysis. Results: The current study demonstrated disrupted topological organization in the whole brain and regional connectivity was associated with inflammatory cytokines of the IL-4, IL-8 and IL-10 levels in BD. Impact: Our study provided preliminary evidence of the association between disrupted brain functional network topology and neuroinflammation in BD.