Non-contrast Portal Venous 4D Flow MRI in an Obese Cohort Undergoing Weight Loss Surgery: Feasibility and Correlations with BMI and MASH
Motivation: To evaluate the potential of portal flow as a biomarker of metabolic-dysfunction associated steatohepatitis (MASH) in obese patients undergoing weight loss surgery (WLS). Goal(s): Determine feasibility of portal non-contrast 4D Flow in obese patients, to assess whether flow is impacted by BMI and the presence of MASH. Approach: Portal flow was quantified at 5 timepoints before and after WLS. Mass conservation and inter-observer agreement assessed validation. Results were correlated with BMI and presence/absence of biopsy-proven MASH. Results: Non-contrast 4D Flow was successful in 339/382 exams (87%); BMI correlated with portal flow (p=0.010); flow was significantly higher in MASH (p=0.013, AUC=0.706) Impact: Our work demonstrates the feasibility of non-contrast 4D flow in individuals with obesity. Further, it indicates possible effects of obesity on portal venous flow and demonstrates its potential as a treatment monitoring tool in MASH.
Authors
- Thekla Oechtering (ORCID: https://orcid.org/0000-0002-1931-1912)
- Kevin M. Johnson (ORCID: https://orcid.org/0000-0002-8660-0853)
- Claude B. Sirlin (ORCID: https://orcid.org/0000-0002-6639-9072)
- Gavin Hamilton (ORCID: https://orcid.org/0000-0001-9302-5546)
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Alejandro Roldán‐Alzate (ORCID: https://orcid.org/0000-0003-4149-4038)
- Anne O. Lidor (ORCID: https://orcid.org/0000-0002-9911-3114)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Michael S. Middleton (ORCID: https://orcid.org/0000-0002-4247-1287)
- Lael Ceriani (ORCID: https://orcid.org/0000-0003-4427-4161)
- Rashmi Agni (ORCID: https://orcid.org/0000-0001-7803-4647)
- David Harris (ORCID: https://orcid.org/0000-0002-1150-8702)
- Luke M. Funk (ORCID: https://orcid.org/0000-0003-4475-304X)
- Danielle Batakis
- Alma Spahic (ORCID: https://orcid.org/0000-0002-7322-5871)
- James R. Goodman (ORCID: https://orcid.org/0000-0001-9486-9898)
- Tanya Wolfson
- Raphael do Vale Souza
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4011
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00