Amygdala Subregion Atrophy: Early Indicator of Cognitive Impairment in Cerebral Small Vessel Disease

Motivation: The motivation behind this study was to delve deeper into the amygdala subregion changes in Cerebral Small Vessel Disease (CSVD) and how these changes correlate with cognitive impairment. Goal(s): The primary goal was to determine whether specific amygdala subregions could serve as early indicator for cognitive impairment in CSVD, thereby aiding in early diagnosis and intervention. Approach: Combined 3T MRI neuroimaging with cognitive assessments and focused statistical evaluation of amygdala subregionsResults: Our study revealed significant volume reductions in specific amygdala subregions among CSVD group, with pronounced atrophy observed in the left cortical nucleus. Impact: This research introduces a novel indicator that utilizes neuroimaging techniques for the early prediction of CSVD progression and associated cognitive impairment, which could significantly enhance the precision of diagnostics and inform effective management strategies for CSVD.