Intracranial EEG information flow is associated with metabolic and structural connectivity in temporal lobe epilepsy

Motivation: EEG measured directional information flow, cerebral metabolism and structural connectivity are altered in temporal lobe epilepsy, although their interplay have not been elucidated. Goal(s): To investigate whether and how structural and metabolic connectivity may separately or jointly affect the directional information flow. Approach: This study proposed a step-wise analysis to study the correlation between directional information flow measured by SEEG and glucose metabolism measured by FDG PET, and to explore their associations with different structural connectivity. Results: The inward information flow was negatively correlated with FDG uptake. White matter structural connectivity modulated the relationship between SEEG information flow and metabolism. Impact: Unraveling the underlying association of white matter connectivity and FDG metabolism with directional information flow strength could offer a comprehensive view of neuronal signal propagation and potentially improve seizure onset localization of focal epilepsy.