Glymphatic dysfunction in patients with Chronic kidney disease is associated with cognitive decline

Motivation: The relationship between CSF inflow, which is an essential physiological activity of the glymphatic system, and cognitive decline in patients with chronic kidney disease (CKD) is unclear. Goal(s): Our goal was to explore the patterns of CSF inflow changes in patients with CKD and its relationship with cognitive decline. Approach: The CSF in the the subarachnoid space along the middle cerebral were analyzed with ultra-long echo time and low-b diffusion tensor imaging. Results: Disturbed CSF inflow patterns is associated with cognitive decline in patients with CKD. Impact: A novel approach to measure the CSF inflow of the glymphatic system exhibits the potential for detecting brain glymphatic dysfunction in patients with CKD, which may be one of the pathogenic mechanisms of cognitive decline.