Targeted MRI (tMRI) of Small Changes in the T1 of White Matter of the Brain in Methamphetamine Dependency Before and After Abstinence.

Motivation: Targeted MRI (tMRI) of small changes in T1 in lesions in normal appearing white matter using divided Subtracted Inversion Recovery (dSIR) sequences can show high contrast and abnormalities that are not seen with conventional IR sequences. Goal(s): To depict subtle changes in T1 in otherwise normal appearing white matter with dSIR images. Approach: Applying tMRI in a patient with methamphetamine dependency before and eight months after abstinence. Results: Widespread abnormalities on dSIR images in areas of normal appearing WM n T2-FLAIR images. There was striking remission of the changes after eight months' abstinence. The changes may be due to neuroinflammation regression with abstinence. Impact: In a patient with methamphetamine dependency, tMRI using dSIR sequences showed striking abnormalities in white matter that appeared normal with T2-FLAIR sequences of the brain. These changes showed marked regression after eight months' abstinence.