Aneurysm Wall Permeability in Assessing Non-Saccular Intracranial Aneurysms Rupture Risk Based on DCE-MRI

Motivation: Evaluating intracranial aneurysm (IA) risk holds significant clinical importance. Recent studies have proposed wall permeability (Ktrans) as a significant risk predictor, but its validity in non-saccular aneurysms remains unclear. Goal(s): Our study aims to predict non-saccular IA rupture by Ktrans from DCE-MRI. Approach: Ktrans was derived from the extended Kety/Tofts model. We analyzed correlation between Ktrans and IA size, the Population, Hypertension, Age, Size, Earlier Subarachnoid Hemorrhage, and Site (PHASES) score and other clinical factors. Results: Ktrans significantly related to IA size and PHASES score, but there was no correlation between Ktrans and intramural hematoma (IMH) and wall enhancement index (WEI). Impact: By analyzing correlation between aneurysm wall permeability (Ktrans) and other risk factors of non-saccular aneurysms rupture, we found that Ktrans might be a risk indicator for rupture of non-saccular IAs.